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27

Exchange of calcium between bone and extracellular fluid takes place under the influence of certain hormones

(a) What will happen if more of $\mathrm{Ca}^{2+}$ is in extracellular fluid?

(b) What will happen if very less amount of $\mathrm{Ca}^{2+}$ is in the extracellular fluid?

Explanation

(a) More $\mathrm{Ca}^{2+}$ concentration in extracellular fluid is associated with hyperparathyroidism. It causes demineralisation, resulting in softening and bending of the bones. This condition leads to osteoporosis.

(b) Very less amount of $\mathrm{Ca}^{2+}$ in extracellular fluid is associated with hypoparathyroidism. This increases the excitability of nerves and muscles, causing cramps, sustained contraction of the muscles of larynx, face, hands and feet. This disorder is called parathyroidtetany or hypercalcemictetany.

28
Name atleast two hormones which result in fluctuation of $\mathrm{Ca}^{2+}$ level.
Explanation
Parathyroid hormone and calcitonin results in the fluctuation of $\mathrm{Ca}^{2+}$ level. Parathyroid Hormone (PTH) increases the $\mathrm{Ca}^{2+}$ levels in the blood. PTH acts on the bones and stimulates the process of bone resorption (dissolution/demineralisation). PTH also stimulates reabsorption of $\mathrm{Ca}^{2+}$ by the renal tubules and increases $\mathrm{Ca}^{2+}$ absorption from the digested food. Calcitonin is a 32-amino acid linear polypeptide hormone, that is produced in humans primarily by the parafollicular cells of the thyroid. It acts by reducing blood calcium $\left(\mathrm{Ca}^{2+}\right)$, levels opposing the effect of Parathyroid Hormone (PTH).
29

Rahul exercises regularly by visiting a gymnasium. Of late he is gaining weight. What could be the reason? Choose the correct answer and elaborate.

(a) Rahul has gained weight due to accumulation of fats in body

(b) Rahul has gained weight due to increased muscle and less of fat

(c) Rahul has gained weight because his muscle shape has improved

(d) Rahul has gained weight because he is accumulating water in the body

Explanation
Rahul has gained weight because his muscle shape has changed. Regular exercise increase the body muscle as there is an enlargement of muscles due to increase in the amount of sarcoplasm and mitochondria and the strength he to developed led him gain the mass and size of body muscle and reduction in fat content.
30

Radha was running on a treadmill at a great speed for 15 minutes continuously. She stopped the treadmill and abruptly came out. For the next few minutes, she was breathing heavily/fast. Answer the following questions.

(a) What happened to her muscles when she did strenuously exercised?

(b) How did her breathing rate change?

Explanation

(a) Due, to continuous exercise her muscles got fatigues because of the accumulation of lactic acid within skeletal muscles. Pain is also oftenly experienced in the fatigued muscles.

(b) Her breathing rate changes from normal to high as during exercise, her body muscle require more oxygen for the ATP production, than the normal value, hence her breathing enhances, to lake most oxygen from the atmosphere.

31
Write a few lines about gout.
Explanation
Gout is a disease, caused due to defect in purine metabolism. It causes accumulation of excess of uric acid and its crystals in the joints. The level of uric acid and crystals of its salts get raised in blood causing their accumulation in the joints causes gouty arthritis. The excess of urates in blood can also lead to the formation stones in the kidneys.